The global laser capture microdissection Market was significantly robust in 2020 and is expected to grow at a rapid revenue compound annual growth rate (CAGR) over the forecast period. Factors that are expected to drive the market's revenue growth include the increasing advancements in LCM, rising investment and funding in healthcare research and development (R&D), and the growing adoption of LCM in laboratories worldwide to accelerate molecular pathology research. LCM enables the rapid and reliable procurement of specific and pure populations of morphologically similar cells for tissue cross-sections, and it allows investigation of subcellular profiles with enhanced accuracy.
DNA, RNA, proteins, and other biomolecules extracted from microdissected cells can be used for various applications, such as polymerase chain reaction, microarray analysis, and proteomic analysis. LCM is widely used to isolate cells from tumor resections to assess molecular events in cancer, toxicological pathology to obtain information about the mechanism of toxicity and study the effects of toxicants on specific cell populations in a heterogeneous mixture, and in forensic science as it enables forensic experts to separate specific sperm cells from mixtures of biological fluids in cases of sexual assault. Applications of LCM have increased drastically to cover research fields such as neurology, cancer research, plant analysis, and forensics.
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However, tissue sections that have undergone LCM demonstrate degradation owing to increased exposure to fixatives and staining reagents. This limits the use of tissues and cells for further analysis and is one of the major growth limiting factors. In addition, LCM is an expensive technique, and the high costs associated with microscopes and other consumables increase the burden of expenses on an organization. These factors are expected to restrain market growth to a certain extent over the forecast period.
Based on the system, the global market has been segmented into ultraviolet LCM, infrared LCM, and immunofluorescence LCM. The ultraviolet LCM segment is expected to account for the largest revenue share in the global market. The pharmaceutical and biotechnology companies segment is expected to register a robust revenue CAGR over the forecast period owing to rising investment in pharmaceutical research and growing adoption of LCM to carry out in vivo analysis of cells such as cancer cells to develop advanced therapeutics.
North America is expected to account for the largest revenue share in the global market owing to the rapid progress of the biopharmaceutical sector, rising technological advancements in research techniques and methods, growing investment to accelerate research and development activities, and increasing incorporation of the technique in molecular diagnostics and forensic sciences. Asia Pacific is expected to register robust revenue CAGR over the forecast period owing to increasing investment in the healthcare sector, the establishment of state-of-the-art research facilities, and rapid progress of the pharmaceutical sector in the region.
Major companies in the global market include Thermo Fisher Scientific, Inc., Danaher Corporation, Carl Zeiss AG, Molecular Machines & Industries, INDIVUMED GmbH, Theranostics Health Inc., Ocimum Biosolutions LLC, DeNova Sciences Pte. Ltd., 3DHISTECH Ltd., and AvanSci Bio LLC. These major players are focusing on extensive research and development activities, product advancements, and strategic alliances such as mergers and acquisitions, partnerships, collaborations, and product launches to cater to growing global demand and to gain a strong foothold in the market. In March 2020, Fluidigm Corporation unveiled the AccuLift Laser Capture Microdissection System for translational and clinical pathology research. The system can precisely and efficiently capture individual cells or large tissue sections for DNA, RNA, and protein biomarker analysis.
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